Regulation of Human Lymphocyte Immune Responses. 1

Regulation of Lymphocyte Responses in Vitro

DNA synthesis of normal rat spleen cells in response to endotoxin increases markedly if adherent cells are first removed from the cell suspension. Addition of small numbers of purified macrophages to the cultures restores the response to a low level. T-deprived cells show these effects in very much lesser degree. Large numbers of macrophages completely suppress the response of both normal and T...

Regulation of Immune Responses By

Exosomes: Mediators of Immune Regulation

Extracellular Vesicles, including exosomes, are small membrane fragments released from many cell types, like Mesenchymal Stem Cells (MSCs). They were recognized as a mechanism of intercellular communication. They can transfer proteins, lipids and nucleic acids to other cells. Thus, they have many physiological (angiogenesis, coagulation and tissue repair, etc.) and pathological (e.g. in autoimm...

Involvement of CD100, a lymphocyte semaphorin, in the activation of the human immune system via CD72: implications for the regulation of immune and inflammatory responses.

CD100/Sema4D belongs to the semaphorin family, factors known to act as repulsive cues for axons during neuronal development. Mouse CD100 plays a crucial role in both humoral and cellular immunity through ligation of the lymphocyte receptor, CD72. It remains controversial, however, whether human CD100 can function through human CD72 in a manner similar to mouse CD100. To determine the function o...

Regulation of immune responses by RBC transfusion

It has long been appreciated that transferring allogeneic tissues between members of the same species can have complicated effects upon the recipient immune system. Transfusion represents the most common exposure to large quantities of alloantigen, which unlike solid organ transplant, occurs in the absence of pharmacological immunosuppression. Transfused products constitute a complex cellular e...